Unique Insights at the RNA–Protein Interface
Ribolytix provides specialized RBP target engagement and selectivity profiling services through two complementary product families that support decision-making from hit confirmation through lead optimization.
Our Services
RBP Selectivity Profiling
(RBP-SP™)
Broad, unbiased selectivity profiling across the RBPome
Label-free, mass-spectrometry–based measurement of cellular target engagement across the RNA-binding proteome. Resolves mechanism-relevant engagement patterns and identifies early selectivity liabilities to inform progression decisions.
RBP Target Engagement
(RBP-TE™)
Focused, quantitative assessment of cellular target engagement
Label-free, cellular target engagement assays that quantify engagement IC₅₀ values and time-dependent engagement kinetics for nominated RNA-binding protein targets to support medicinal chemistry optimization..
The Ribolytix platform at a glance
Native Biology
Measures target engagement in intact cells under native conditions, supporting translational relevance and reducing artifacts associated with cell-free or overexpression systems.
Label and tag-free
Quantifies native, endogenous targets without engineered tags, fluorescent labels, or protein overexpression that can distort biology and generate false positives.
No Stability Assumptions
Directly quantifies target engagement via RNA–protein interaction state rather than inferring binding from stability shifts, providing mechanism-coupled readouts relevant to RBP target biology.
Ribolytix delivers biologically relevant engagement and selectivity readouts for RBP- and RNA-targeted therapies, directly measuring RNA–protein interactions in cells, enabling earlier and more confident prioritization of drug candidates during early discovery and lead optimization.
Discover how our platform can tackle your drug discovery challenges and unlock new therapeutic opportunities. Get in touch or book a free scoping call with one of our experts.